{"id":18103,"date":"2020-09-02T18:42:17","date_gmt":"2020-09-02T18:42:17","guid":{"rendered":"https:\/\/www.xatakaciencia.com\/medicina\/se-destruyen-celulas-cancerosas-mama-laboratorio-gracias-al-veneno-abeja"},"modified":"2020-09-02T18:42:17","modified_gmt":"2020-09-02T18:42:17","slug":"se-destruyen-celulas-cancerosas-de-mama-en-laboratorio-gracias-al-veneno-de-la-abeja","status":"publish","type":"post","link":"http:\/\/forocilac.org\/en\/se-destruyen-celulas-cancerosas-de-mama-en-laboratorio-gracias-al-veneno-de-la-abeja\/","title":{"rendered":"Breast cancer cells are destroyed in the laboratory thanks to bee venom"},"content":{"rendered":"<p>\n      <img decoding=\"async\" src=\"https:\/\/i.blogs.es\/99924c\/1920px-wasp_attack\/1024_2000.jpg\" alt=\"Se destruyen c\u00e9lulas cancerosas de mama en laboratorio gracias al veneno de la abeja\">\n    <\/p>\n<p>Un nuevo estudio de laboratorio muestra que una mol\u00e9cula que se encuentra en el veneno de abeja puede suprimir el crecimiento de c\u00e9lulas cancerosas particularmente desagradables.<\/p>\n<p><!-- BREAK 1 --><\/p>\n<p>He <a href=\"https:\/\/www.nature.com\/articles\/s41698-020-00129-0\">study<\/a> <strong>se ha centrado en ciertos subtipos de c\u00e1ncer de mama<\/strong>, incluido el c\u00e1ncer de mama triple negativo (TNBC), que es una afecci\u00f3n extremadamente agresiva con opciones de tratamiento limitadas.<\/p>\n<p><!-- BREAK 2 --><!--more--><\/p>\n<h2>TNBC<\/h2>\n<p><strong>El TNBC representa hasta el 15 % de todos los c\u00e1nceres de mama<\/strong>. Para ser tratados se necesita diferentes tipos de tratamientos porque son receptores de estr\u00f3geno negativos, receptores de progesterona negativos y HER2 negativos. Los medicamentos como el tamoxifeno, que se dirige al receptor de estr\u00f3geno, y el trastuzumab (Herceptin), que se dirige al HER2, no son \u00fatiles para tratar el c\u00e1ncer de mama triple negativo.<\/p>\n<p><!-- BREAK 3 --><\/p>\n<div class=\"article-asset article-asset-normal article-asset-center\">\n<div class=\"desvio-container\">\n<div class=\"desvio\">\n<div class=\"desvio-figure js-desvio-figure\">\n    <a href=\"https:\/\/www.xatakaciencia.com\/medio-ambiente\/desaparicion-abejas-podria-estar-causandola-herbicida-comun\" ><br \/>\n     <img decoding=\"async\" alt=\"La&#x20;desaparici&#x00F3;n&#x20;de&#x20;abejas&#x20;podr&#x00ED;a&#x20;estar&#x20;caus&#x00E1;ndola&#x20;un&#x20;herbicida&#x20;com&#x00FA;n&#x20;\" src=\"https:\/\/i.blogs.es\/e9c500\/fotonoticia_20180925103555_640\/375_142.jpg\"><br \/>\n    <\/a>\n   <\/div>\n<div class=\"desvio-summary\">\n<div class=\"desvio-taxonomy js-desvio-taxonomy\">\n     <a href=\"https:\/\/www.xatakaciencia.com\/medio-ambiente\/desaparicion-abejas-podria-estar-causandola-herbicida-comun\" class=\"desvio-taxonomy-anchor\">In Xataka Science<\/a>\n    <\/div>\n<p>    <a href=\"https:\/\/www.xatakaciencia.com\/medio-ambiente\/desaparicion-abejas-podria-estar-causandola-herbicida-comun\" class=\"desvio-title js-desvio-title\">La desaparici\u00f3n de abejas podr\u00eda estar caus\u00e1ndola un herbicida com\u00fan <\/a>\n   <\/div><\/div><\/div>\n<\/div>\n<p>He <strong>bee venom<\/strong> (<em>Apis mellifera<\/em>), sin embargo, ha mostrado potencial en otras terapias m\u00e9dicas como el tratamiento del eccema, y \u200b\u200bse sabe desde hace alg\u00fan tiempo que tiene propiedades antitumorales, incluido el melanoma. Con todo, no se comprende completamente c\u00f3mo funciona contra los tumores a nivel molecular. Ahora, no obstante, se ha dado un gran paso hacia la respuesta.<\/p>\n<p><!-- BREAK 4 --><\/p>\n<p>Bees really use <strong>melittin<\/strong>, la mol\u00e9cula que constituye la mitad de su veneno y hace que sus picaduras sean dolorosas, para combatir sus propios pat\u00f3genos. Los insectos producen este p\u00e9ptido no solo en su veneno, sino tambi\u00e9n en otros tejidos, donde se expresa en respuesta a infecciones. Con la mira puesta en esta mol\u00e9cula, los investigadores sometieron c\u00e9lulas cancerosas y c\u00e9lulas normales cultivadas en laboratorio al veneno de abeja de Irlanda, Inglaterra y Australia, y al veneno de abejorro (<em>Bombus terrestris<\/em>) from England.<\/p>\n<p><!-- BREAK 5 --><\/p>\n<div class=\"article-asset article-asset-normal article-asset-center\">\n<div class=\"desvio-container\">\n<div class=\"desvio\">\n<div class=\"desvio-figure js-desvio-figure\">\n    <a href=\"https:\/\/www.xatakaciencia.com\/biologia\/gente-suele-preferir-abejas-a-avispas-deberiamos-reconsiderarlo\" ><br \/>\n     <img decoding=\"async\" alt=\"La&#x20;gente&#x20;suele&#x20;preferir&#x20;las&#x20;abejas&#x20;a&#x20;las&#x20;avispas,&#x20;pero&#x20;deber&#x00ED;amos&#x20;reconsiderarlo&#x20;\" src=\"https:\/\/i.blogs.es\/8bf1db\/3168822965_aa917066ba_o\/375_142.jpg\"><br \/>\n    <\/a>\n   <\/div>\n<div class=\"desvio-summary\">\n<div class=\"desvio-taxonomy js-desvio-taxonomy\">\n     <a href=\"https:\/\/www.xatakaciencia.com\/biologia\/gente-suele-preferir-abejas-a-avispas-deberiamos-reconsiderarlo\" class=\"desvio-taxonomy-anchor\">In Xataka Science<\/a>\n    <\/div>\n<p>    <a href=\"https:\/\/www.xatakaciencia.com\/biologia\/gente-suele-preferir-abejas-a-avispas-deberiamos-reconsiderarlo\" class=\"desvio-title js-desvio-title\">La gente suele preferir las abejas a las avispas, pero deber\u00edamos reconsiderarlo <\/a>\n   <\/div><\/div><\/div>\n<\/div>\n<p>El veneno de abejorro, que no contiene melitina, tuvo poco efecto sobre las c\u00e9lulas del c\u00e1ncer de mama, pero el veneno de abeja de todos los lugares s\u00ed marc\u00f3 la diferencia. De hecho, <strong>la melitina puede destruir completamente las membranas de las c\u00e9lulas cancerosas en 60 minutos<\/strong>.<\/p>\n<p><!-- BREAK 6 --><\/p>\n<p>Adem\u00e1s, por si esto fuera poco, la melitina tuvo poco impacto en las c\u00e9lulas normales, dirigi\u00e9ndose espec\u00edficamente a las c\u00e9lulas que produc\u00edan una gran cantidad de EGFR y HER2 (otra mol\u00e9cula producida en exceso por algunos tipos de c\u00e1ncer de mama); <strong>incluso estrope\u00f3 la capacidad de replicaci\u00f3n de las c\u00e9lulas cancerosas<\/strong>.<\/p>\n<p><!-- BREAK 7 --><\/p>\n<p>Tras probar lo mismo con una versi\u00f3n sint\u00e9tica de melitina, descubrieron los mismos resultados. <\/p>\n<div class=\"article-asset article-asset-normal article-asset-center\">\n<div class=\"desvio-container\">\n<div class=\"desvio\">\n<div class=\"desvio-figure js-desvio-figure\">\n    <a href=\"https:\/\/www.xatakaciencia.com\/medio-ambiente\/si-desaparecen-los-insectos-la-economia-mundial-sufriria-un-enorme-retroceso\" ><br \/>\n     <img decoding=\"async\" alt=\"Si&#x20;desaparecen&#x20;los&#x20;insectos,&#x20;la&#x20;econom&#x00ED;a&#x20;mundial&#x20;sufrir&#x00ED;a&#x20;un&#x20;enorme&#x20;retroceso\" src=\"https:\/\/i.blogs.es\/a87356\/412316027_a7e6548fe8_o\/375_142.jpg\"><br \/>\n    <\/a>\n   <\/div>\n<div class=\"desvio-summary\">\n<div class=\"desvio-taxonomy js-desvio-taxonomy\">\n     <a href=\"https:\/\/www.xatakaciencia.com\/medio-ambiente\/si-desaparecen-los-insectos-la-economia-mundial-sufriria-un-enorme-retroceso\" class=\"desvio-taxonomy-anchor\">In Xataka Science<\/a>\n    <\/div>\n<p>    <a href=\"https:\/\/www.xatakaciencia.com\/medio-ambiente\/si-desaparecen-los-insectos-la-economia-mundial-sufriria-un-enorme-retroceso\" class=\"desvio-title js-desvio-title\">Si desaparecen los insectos, la econom\u00eda mundial sufrir\u00eda un enorme retroceso<\/a>\n   <\/div><\/div><\/div>\n<\/div>\n<p>Antes de entusiasmarse, cabe advertir que muchas cosas pueden matar una c\u00e9lula cancerosa en una placa de Petri, y los investigadores advierten que a\u00fan queda un largo camino por recorrer antes de que esta mol\u00e9cula de veneno de abeja pueda potencialmente usarse como tratamiento en humanos.<\/p>\n<p><!-- BREAK 8 --><script>\n (function() {\n  window._JS_MODULES = window._JS_MODULES || {};\n  var headElement = document.getElementsByTagName('head')[0];\n  if (_JS_MODULES.instagram) {\n   var instagramScript = document.createElement('script');\n   instagramScript.src = 'https:\/\/platform.instagram.com\/en_US\/embeds.js';\n   instagramScript.async = true;\n   instagramScript.defer = true;\n   headElement.appendChild(instagramScript);\n  }\n })();\n<\/script><\/p>\n<p> &#8211; <br \/> The news<br \/>\n      <a href=\"https:\/\/www.xatakaciencia.com\/medicina\/se-destruyen-celulas-cancerosas-mama-laboratorio-gracias-al-veneno-abeja?utm_source=feedburner&#038;utm_medium=feed&#038;utm_campaign=02_Sep_2020\"><br \/>\n       <em> Breast cancer cells are destroyed in the laboratory thanks to bee venom <\/em><br \/>\n      <\/a><br \/>\n      was originally published in<br \/>\n      <a href=\"https:\/\/www.xatakaciencia.com\/?utm_source=feedburner&#038;utm_medium=feed&#038;utm_campaign=02_Sep_2020\"><br \/>\n       <strong> Xataka Science <\/strong><br \/>\n      <\/a><br \/>\n            by <a\n       href=\"https:\/\/www.xatakaciencia.com\/autor\/sergio-parra?utm_source=feedburner&#038;utm_medium=feed&#038;utm_campaign=02_Sep_2020\"><br \/>\n       Sergio Parra<br \/>\n      <\/a><br \/>\n      . <\/p>\n<p><img decoding=\"async\" src=\"http:\/\/feeds.feedburner.com\/~r\/xatakaciencia\/~4\/Gli1GVyNGQA\" height=\"1\" width=\"1\" alt=\"\"\/><\/p>","protected":false},"excerpt":{"rendered":"<p>\n      <img decoding=\"async\" src=\"https:\/\/i.blogs.es\/99924c\/1920px-wasp_attack\/1024_2000.jpg\" alt=\"Se destruyen c&eacute;lulas cancerosas de mama en laboratorio gracias al veneno de la abeja\"><\/p>\n<p>A new lab study shows that a molecule found in bee venom can suppress the growth of particularly nasty cancer cells.<\/p>\n<p><!-- BREAK 1 --><\/p>\n<p>He <a href=\"https:\/\/www.nature.com\/articles\/s41698-020-00129-0\">study<\/a> <strong>has focused on certain subtypes of breast cancer<\/strong>, including triple negative breast cancer (TNBC), which is an extremely aggressive condition with limited treatment options.<\/p>\n<p><!-- BREAK 2 --><!--more--><\/p>\n<h2>TNBC<\/h2>\n<p><strong>TNBC accounts for up to 15 % of all breast cancers<\/strong>. To be treated, different types of treatments are needed because they are estrogen receptor negative, progesterone receptor negative and HER2 negative. Drugs such as tamoxifen, which targets the estrogen receptor, and trastuzumab (Herceptin), which targets HER2, are not helpful in treating triple-negative breast cancer.<\/p>\n<p><!-- BREAK 3 --><\/p>\n<div>\n<div>\n<div>\n<div>\n    <a href=\"https:\/\/www.xatakaciencia.com\/medio-ambiente\/desaparicion-abejas-podria-estar-causandola-herbicida-comun\"><br \/>\n     <img decoding=\"async\" alt=\"La desaparici&oacute;n de abejas podr&iacute;a estar caus&aacute;ndola un herbicida com&uacute;n \" src=\"https:\/\/i.blogs.es\/e9c500\/fotonoticia_20180925103555_640\/375_142.jpg\"><\/a>\n   <\/div>\n<div>\n<div>\n     <a href=\"https:\/\/www.xatakaciencia.com\/medio-ambiente\/desaparicion-abejas-podria-estar-causandola-herbicida-comun\">In Xataka Science<\/a>\n    <\/div>\n<p>    <a href=\"https:\/\/www.xatakaciencia.com\/medio-ambiente\/desaparicion-abejas-podria-estar-causandola-herbicida-comun\">The disappearance of bees could be caused by a common herbicide <\/a>\n   <\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<p>He <strong>bee venom<\/strong> (<em>Apis mellifera<\/em>), however, it has shown potential in other medical therapies such as treating eczema, and has been known for some time to have anti-tumor properties, including melanoma. However, how it works against tumors at the molecular level is not fully understood. Now, however, a big step has been taken towards the answer.<\/p>\n<p><!-- BREAK 4 --><\/p>\n<p>Bees really use <strong>melittin<\/strong>, the molecule that makes up half of its venom and makes its bites painful, to combat its own pathogens. Insects produce this peptide not only in their venom, but also in other tissues, where it is expressed in response to infections. With their sights set on this molecule, the researchers subjected lab-grown cancer cells and normal cells to bee venom from Ireland, England, and Australia, and bumblebee venom (<em>Bombus terrestris<\/em>) from England.<\/p>\n<p><!-- BREAK 5 --><\/p>\n<div>\n<div>\n<div>\n<div>\n    <a href=\"https:\/\/www.xatakaciencia.com\/biologia\/gente-suele-preferir-abejas-a-avispas-deberiamos-reconsiderarlo\"><br \/>\n     <img decoding=\"async\" alt=\"La gente suele preferir las abejas a las avispas, pero deber&iacute;amos reconsiderarlo \" src=\"https:\/\/i.blogs.es\/8bf1db\/3168822965_aa917066ba_o\/375_142.jpg\"><\/a>\n   <\/div>\n<div>\n<div>\n     <a href=\"https:\/\/www.xatakaciencia.com\/biologia\/gente-suele-preferir-abejas-a-avispas-deberiamos-reconsiderarlo\">In Xataka Science<\/a>\n    <\/div>\n<p>    <a href=\"https:\/\/www.xatakaciencia.com\/biologia\/gente-suele-preferir-abejas-a-avispas-deberiamos-reconsiderarlo\">People usually prefer bees to wasps, but we should reconsider <\/a>\n   <\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<p>Bumblebee venom, which does not contain melittin, had little effect on breast cancer cells, but bee venom of all places did make a difference. In fact, <strong>melittin can completely destroy cancer cell membranes within 60 minutes<\/strong>.<\/p>\n<p><!-- BREAK 6 --><\/p>\n<p>Furthermore, if this were not enough, melittin had little impact on normal cells, specifically targeting cells that produced a large amount of EGFR and HER2 (another molecule produced in excess by some types of breast cancer); <strong>it even spoiled the ability of cancer cells to replicate<\/strong>.<\/p>\n<p><!-- BREAK 7 --><\/p>\n<p>After trying the same thing with a synthetic version of melittin, they discovered the same results. <\/p>\n<div>\n<div>\n<div>\n<div>\n    <a href=\"https:\/\/www.xatakaciencia.com\/medio-ambiente\/si-desaparecen-los-insectos-la-economia-mundial-sufriria-un-enorme-retroceso\"><br \/>\n     <img decoding=\"async\" alt=\"Si desaparecen los insectos, la econom&iacute;a mundial sufrir&iacute;a un enorme retroceso\" src=\"https:\/\/i.blogs.es\/a87356\/412316027_a7e6548fe8_o\/375_142.jpg\"><\/a>\n   <\/div>\n<div>\n<div>\n     <a href=\"https:\/\/www.xatakaciencia.com\/medio-ambiente\/si-desaparecen-los-insectos-la-economia-mundial-sufriria-un-enorme-retroceso\">In Xataka Science<\/a>\n    <\/div>\n<p>    <a href=\"https:\/\/www.xatakaciencia.com\/medio-ambiente\/si-desaparecen-los-insectos-la-economia-mundial-sufriria-un-enorme-retroceso\">If insects disappear, the world economy would suffer a huge setback<\/a>\n   <\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<p>Before you get excited, it&#039;s worth warning that many things can kill a cancer cell in a petri dish, and researchers warn that there is still a long way to go before this bee venom molecule can potentially be used as a treatment in humans.<\/p>\n<p><!-- BREAK 8 --><\/p>\n<p> &#8211; <br \/> The news<br \/>\n      <a href=\"https:\/\/www.xatakaciencia.com\/medicina\/se-destruyen-celulas-cancerosas-mama-laboratorio-gracias-al-veneno-abeja?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=02_Sep_2020\"><br \/>\n       <em> Breast cancer cells are destroyed in the laboratory thanks to bee venom <\/em><br \/>\n      <\/a><br \/>\n      was originally published in<br \/>\n      <a href=\"https:\/\/www.xatakaciencia.com\/?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=02_Sep_2020\"><br \/>\n       <strong> Xataka Science <\/strong><br \/>\n      <\/a><br \/>\n            by <a href=\"https:\/\/www.xatakaciencia.com\/autor\/sergio-parra?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=02_Sep_2020\"><br \/>\n       Sergio Parra<br \/>\n      <\/a><br \/>\n      . <\/p>\n<p><img decoding=\"async\" src=\"http:\/\/feeds.feedburner.com\/~r\/xatakaciencia\/~4\/Gli1GVyNGQA\" height=\"1\" width=\"1\" alt=\"\"><\/p>","protected":false},"author":19,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[125],"tags":[],"class_list":{"0":"post-18103","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-portal-3"},"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/forocilac.org\/en\/wp-json\/wp\/v2\/posts\/18103","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/forocilac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/forocilac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/forocilac.org\/en\/wp-json\/wp\/v2\/users\/19"}],"replies":[{"embeddable":true,"href":"http:\/\/forocilac.org\/en\/wp-json\/wp\/v2\/comments?post=18103"}],"version-history":[{"count":0,"href":"http:\/\/forocilac.org\/en\/wp-json\/wp\/v2\/posts\/18103\/revisions"}],"wp:attachment":[{"href":"http:\/\/forocilac.org\/en\/wp-json\/wp\/v2\/media?parent=18103"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/forocilac.org\/en\/wp-json\/wp\/v2\/categories?post=18103"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/forocilac.org\/en\/wp-json\/wp\/v2\/tags?post=18103"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}