Within the small volume of a single cell, reactants are bound together in a confined space through highly evolved chemical recognition events. The way nature controls chemical reactivity within a cell is what any organic chemist could dream of: multiple reactions that can be specifically controlled in complex mixtures without any cross-reactivity.
Inspired by this, a group of researchers from the University of Rome has published A study in Nature in which the use of antibodies to control chemical reactions is demonstrated.
IgG antibodies
The study has thus demonstrated the possibility of using bivalent biomolecules (i.e., IgG antibodies) to induce proximity between reagents and thus control their chemical reactivity.
For the first time, therefore, the possibility of controlling reactions with antibodies is opened, which allows the formation of reaction products to be controlled, and that these are generated only in the presence of specific antibodies.
These reaction products can be designed to be functional molecules, with therapeutic use, for example.
In this specific study, the formation of an anticoagulant agent is demonstrated through the reaction induced by the presence of the specific antibody. We see how only in the presence of the antibody in question, the anticoagulant agent is formed and then inhibits the activity of thrombin (a key enzyme in blood clotting).
The strategy is very versatile, allowing it to be applied to any type of reaction (that is, generating a wide variety of products) and to be designed for any type of IgG antibody.
IgG antibodies are notable biomarkers; They are the signs that provide us with indications about many diseases and how our immune system counteracts them. The potential ability of IgG antibodies to control chemical reactions would allow the formation of different molecules, ranging from imaging to therapeutic agents, only when a specific diagnostic IgG antibody is present in our body. It is thus predicted that this strategy could find applications in diagnosis and therapy.
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The news
It is possible to use antibodies to control chemical reactions and form certain types of molecules with therapeutic use
was originally published in
Xataka Science
by
Sergio Parra
.